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Boston Heart Diagnostics

Boston Heart HDL Map ® Test

$115.00 per Test Kit

The Boston Heart HDL Map® is the only test available that quantifies the amount of apoA-I in the five most significant subpopulations, resulting in a deeper understanding of a patient’s CVD risk. This exclusive method provides healthcare providers with an accurate and consistent indication of reverse cholesterol transport by separating the larger, cardioprotective particles most associated with decreased CVD risk from the smaller HDL particles associated with increased risk. Healthcare providers can use this information to determine the most effective treatment strategy, as well as monitor response to therapy.

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Description

For more than forty years, total circulating HDL cholesterol (HDL-C) has been used as a primary indicator of cardiovascular disease (CVD) risk. However, HDL is comprised of subpopulations of different sizes, composition and characteristics that impact cardiovascular risk in drastically different ways.

Data from the Framingham Heart Study, Framingham Offspring Study, Veterans Affairs HDL Cholesterol Intervention Trial (VA-HIT) and HDL-Atherosclerosis Treatment Study (HATS) have shown that HDL subpopulations are significantly better predictors of CVD risk than HDL-C values alone.

The Boston Heart HDL Map® is the only test available that quantifies the amount of apoA-I in the five most significant subpopulations, resulting in a deeper understanding of a patient’s CVD risk. This exclusive method provides healthcare providers with an accurate and consistent indication of reverse cholesterol transport by separating the larger, cardioprotective particles most associated with decreased CVD risk from the smaller HDL particles associated with increased risk. Healthcare providers can use this information to determine the most effective treatment strategy, as well as monitor response to therapy.

Product Details

The Boston Heart HDL Map® test measures the five most significant high-density lipoprotein (HDL) subpopulations in cardiovascular disease (CVD) risk using a proprietary gel electrophoresis technique. This process quantifies the amount of apoA-I protein in each of the five HDL subclasses, providing information to accurately identify patients at increased CVD risk.

 

Reference Ranges:

Male

Optimal Borderline Increased Risk
mg/dL
α-1 >35.0 25.0-35.0 <25.0
α-2 >55.0 45.0-55.0 <45.0
α-3 <20.0 20.0-25.0 >25.0
α-4 <20.0 20.0-25.0 >25.0
Preβ-1 <20.0 20.0-25.0 >25.0

Female

Optimal Borderline Increased Risk
mg/dL
α-1 >45.0 35.0-45.0 <35.0
α-2 >65.0 55.0-65.0 <55.0
α-3 <20.0 20.0-25.0 >25.0
α-4 <20.0 20.0-25.0 >25.0
Preβ-1 <20.0 20.0-25.0 >25.0

Clinical Significance

Low α-1 level is a significant predictor of recurrent CVD events1

  • Low levels of α-1 HDL and high levels of pre ß-1 HDL predicted recurrent CVD events versus no recurrence in men selected for low HDL-C (<40 mg/dL) and CVD. Low α-1 HDL levels have been shown to be the most significant parameter predicting CVD recurrence (p<0.001).1

References:

1. Asztalos BF, Cupples LA, Demissie S, Horvath KV, Cox CE, Batista MC, Schaefer EJ. High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants in the Framingham Off spring Study. Arterioscler Thromb Vasc Biol. 2004; 24(11):2181-2187.

 

Potential Treatment Options

  • Lifestyle modification (if indicated)
    • Low saturated fat (<7%)
    • Low cholesterol (<200 mg/day)
    • Low sugar
  • Exercise >30 minutes per day
  • Smoking cessation
  • Weight reduction (if indicated)
  • Medications and their impact on HDL Particles
Sample Details

Preferred Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Methodology

Proprietary PAGE system

Patient Preparation

Fasting is preferred.

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated:  2 days (sample must be received within 2 days of collection)

Payment Methods
  • Credit Card
  • HSA Card
  • ACH
  • PayPal
  • PO Number

Note: These products and services are not returnable.

Questions?

Call (888) 204-5303 or email support@meenta.io

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