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Genesys Diagnostics Familial Hypercholesterolemia Panel

Genesys Diagnostics
SKU: GDI14

$750.00 per test

Helps individuals who want to detect risk of high cholesterol due to genetics and family risk by using the latest next generation sequencing analysis because unlike any other Clinical Diagnostics marketplace Meenta offers unfettered access to validated tests.

 

Helps individuals who want to detect risk of high cholesterol due to genetics and family risk by using the latest next generation sequencing analysis because unlike any other Clinical Diagnostics marketplace Meenta offers unfettered access to validated tests.

 

The Fine Print

Purpose: Detect risk of High Cholesterol due to genetics and family risk.

Benefits:

  • Reveals genetic risk in yourself and close relatives
  • Comprehensive genetic test for high cholesterol
  • Outlines hereditary mutations that can reveal increased risk to future generations
  • Analyzes 15 cardiac genes 
  • Helps inform helpful healthcare and lifestyle changes
  • Sample type: Cheek swab

Technology: Next Generation Sequencing

Turnaround time: 3-4 weeks from receipt in lab

Familial High Cholesterol can lead to very high levels in the bloodstream.  This can then go on to develop into heart disease and cardiovascular problems. 

Foods that come from animals are used in the body to produce a waxy, fat-like substance that is called Cholesterol.   While the body needs some cholesterol to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion, people with familial hypercholesterolemia are unable to get rid of excess cholesterol, and it builds up in the blood. This build up is what increases the risk of developing heart disease to the point that familial hypercholesterolemia affects an estimated 1 in 200-250 people in most countries.  Familial Hypercholesterolemia is believed to be the most common inherited condition causing cardiovascular disease.1. 

Individuals with unexplained elevated cholesterol or early cardiovascular disease may benefit from the confirmation of an FH diagnosis through genetic testing to inform therapeutic management. Early and appropriate medical intervention can reduce the risk of cardiovascular events for individuals.  The Centers for Disease Control (CDC) Office of Public Health Genomics has categorized genetic testing for FH as a “Tier 1” classification, which indicates that there is evidence to support the use of this genetic test in medical practice.

Familial hypercholesterolemia (FH) increases risk for heart disease or stroke due to mutations leading to very high cholesterol levels from an early age.  The Centers for Disease Control (CDC) considers genetic based testing for FH as “Tier 1” classification – genomic applications that have significant potential for positive impact on public health based on available evidence-based guidelines and recommendations.

1MedlinePlus [Internet]. Bethesda (MD): National Library of Medicine (US); [updated Jun 24; cited 2020 Jul 1].   Familial hypercholesterolemia. [Last updated January 1, 2020]  Available at: https://medlineplus.gov/genetics/condition/familial-hypercholesterolemia/#frequency

 
This test includes:

APOA4, APOA5, APOB, CETP, CREB3L3, GCKR, GPIHBP1, HADHA, LDLR, LDLRAP1, LMF1, LPL, PCSK9, SREBF2, ZHX3

How do I interpret the results?

Genetic counseling is generally recommended for any individual taking this test and their family. A medical provider can request reanalysis of the variants, and this is recommended on an annual basis. Data from this next-generation sequencing analysis can be reassessed for the presence of any new variants that may be newly linked to established genes or to newly characterized genes and/or disorders identified since the data used in this report was generated. A charge may be applied for reanalysis. Please contact support@meenta.io for more information at the time reanalysis is requested.
Cheek swab in viral transport media shipped at room temperature

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