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Hereditary Breast and Ovarian Cancer Panel Sequencing

Genesys Diagnostics
SKU: GDI06

$3,200.00 per test

Helps individuals who have a personal or family history which suggests a risk of a hereditary breast and ovarian cancer syndrome by using the next generation sequencing because unlike any other Clinical Diagnostics marketplaces Meenta offers unfettered access to validated tests by providing the latest screening, predictive, and diagnostic testing available in a single Marketplace with full support and 24/7 access to a compendium of tests and the ability to order any test to better inform their health.

Available on backorder

Helps individuals who have a personal or family history which suggests a risk of a hereditary breast and ovarian cancer syndrome by using the next generation sequencing because unlike any other Clinical Diagnostics marketplaces Meenta offers unfettered access to validated tests by providing the latest screening, predictive, and diagnostic testing available in a single Marketplace with full support and 24/7 access to a compendium of tests and the ability to order any test to better inform their health.

The Fine Print

Purpose: To detect gene variants associated with inherited breast and ovarian cancers

Benefits:

  • Comprehensive genetic analysis of 20 genes connected to inherited cancers
  • Early detection is the key to preventative and/or proper treatment of inherited cancers.
  • Early detection can greatly improve prognosis
  • Rapid screen for high-risk patients

Sample type: Cheek swab

Technology: Next Generation Sequencing

Turnaround time: 21-42 business days

This test is appropriate for anyone with a personal or family history which suggests a risk of a hereditary breast and ovarian cancer syndrome. Warning signs for hereditary breast and ovarian cancer could include onset of cancer prior to the age of 50 years, more than one primary cancer in a single person, and/or multiple affected people within a family. 

Anyone identified with hereditary breast and ovarian cancer can benefit from increased surveillance and preventative steps to better manage their risk for cancer.  Also, if an inherited susceptibility is found, your family members can be tested to help define their risk. If a pathogenic variant is identified in you, close relatives (children, siblings, parents) could have as high as a 50% risk to also be at increased risk.

Your genes carry a story that is unique to you and makes you who you are. Genetic testing may help to better understand your chances of developing cancers. Genetic testing for hereditary cancer includes genes that are linked to an increased lifetime risk for multiple cancers such as breast, colorectal, ovarian, uterine, and others. Based on your results, you may want to discuss more specific cancer risks for you and your family with your primary care physician. 

 

How is the test performed?

Sequencing of selected genes is completed using Next Generation Sequencing and the data is analyzed to identify both previously classified and novel variants in targeted genes. A total of 20 genes with previous implications in various mendelian disorders are covered with a minimum read depth of 20X. Note that this test cannot exclude the possibility of variants in genes not analyzed or assayed with incomplete coverage. This test is designed to detect individuals with a germline pathogenic variant, and has only been validated to detect mosaicism above the level of 20%. Mosaicism occurs when a person has two or more sets of cells in their body with different genetic makeup.

What does this test detect?

  • Extended High-Risk Breast Cancer Panel: ATM, BARD1, BRCA1, BRCA2, BRIP1, CHD1, CHEK2, EPAM, FANCC, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, PTEN, RADS1C, RADS1D, STK11, TP53

What does BRCA1 (BReast CAncer gene 1) test for?

BRCA1 is involved with Hereditary Breast, Ovarian, Uterine, Prostate and possibly melanoma cancer.

Why test for hereditary cancer?

Your genes carry a story that is unique to you and makes you who you are. Genetic testing may help to better understand your chances of developing cancers. Genetic testing for hereditary cancer includes genes that are linked to an increased lifetime risk for multiple cancers such as breast, colorectal, ovarian, uterine, and others. Based on your results, your healthcare provider may discuss more specific cancer risks for you and your family. 

Who Should be Tested? 

Test results may affect you and your family. As such, screening/cancer treatment guidelines are in place to determine who should be tested. Some criteria that can be used to determine high-risk patients are below, but please contact your primary care physician to discuss this test before ordering: 

Can I view a sample report?

Yes, a sample report is available here.

What is the turnaround time for this test?

21 to 42 business days from when the lab receives the sample

 
Cheek swab in viral transport media shipped at room temperature

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