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High Risk Hereditary Cancer Panel

Genesys Diagnostics
SKU: GDI25

$3,200.00 per test

Helps high risk individuals who want to know their own risk of inherited cancer conditions by using the latest genetic techniques because unlike any other Clinical Diagnostics marketplace Meenta offers unfettered access to validated tests.  

Helps high risk individuals who want to know their own risk of inherited cancer conditions by using the latest genetic techniques because unlike any other Clinical Diagnostics marketplace Meenta offers unfettered access to validated tests.  

The Fine Print

Purpose: Detect risk of hereditary Cancer

Benefits:

  • Analyzes 16 genes involved in inherited cancer conditions
  • Helps inform helpful healthcare and lifestyle changes
  • Reveals genetic risk in yourself and close relatives
  • Comprehensive genetic test
  • Outlines hereditary mutations that can reveal increased risk to future generations

Sample type: Cheek swab

Technology: Next Generation Sequencing

Turnaround time: 3-4 weeks from receipt in lab

Adenomatous polyposis coli (APC) is a suppressor gene, meaning that it suppresses the growth of tumors.. An abnormal APC gene is unstable and more likely to undergo changes that may lead to colon and rectal cancers.

In hereditary breast and ovarian cancer often there are abnormal BReast CAncer 1 (BRCA1) and BReast CAncer 2 (BRCA2) genes.In addition, if an abnormal ATM gene is inherited, then there is a higher risk for breast and other cancers. 

If there is an abnormality (mutation) in the CDH1 gene, there is a high risk for developing hereditary diffuse gastric cancer (HDGC) which is a very aggressive form of stomach cancer. It also can put women at risk for lobular breast cancer.  This is the second most common form of breast cancer and it  begins in lobules (the milk-producing glands).

A CHEK2 gene mutation will increase the risk of cancer but the risk varies depending on the specific CHEK2 mutation.. Most CHEK2 mutations increase your risk for breast cancer.

Lynch syndrome iis an increased risk of internal organ cancers that are associated with mutations in repair genes, including MLH1, MSH2, MSH6, and PMS2. Muir-Torre syndrome (mutation of MSH6 gene) is a type  of Lynch syndrome that iincreases the risk of certain skin tumors.  Certain EPCAM gene abnormalities are connected with Lynch syndrome which increasses the risk of colorectal and endometrial (Uterine) cancers. If the mutation is in the MLH2 gene there is an  increased risk of colorectal, endometrial/uterine, stomach, ovarian, small bowel, and other types of cancer.

The MUTH gene is a repair gene but when it mutates it stops repairing DNA which then allows for abnormal growth,  This increases your risk for certain types of cancers.which varies depending if 1 or 2 MUTYH mutations are present. One Mutyh mutation only slightly increases risk colorectal cancer. Two MUTYH mutations causes a condition known as MAP (MUTYH-Associated Polyposis (MAP). MAP increases the risk of cancer and polyps of the Colon, rectum and small intestine (small bowel). MAP less commonly may lead to thyroid cancer, ovarian cancer and bladder cancer.

PALB2 (Partner and Localizer of BRCA2) works with BRCA2 to repair damaged DNA.  A mutation of this gene can lead to breast, ovarian or pancreatic cancer in women and pancreatic cancer in men.

PTEN normally acts a suppressor gene stopping cells from growing too fast.  If a mutation occurs in this gene there is an increase risk of various types of cancers including prostate, uterine,, and some types of brain tumors.

 

his test includes:

APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, PTEN, STK11, TP53

How do I interpret the results?

Genetic counseling is generally recommended for any individual taking this test and their family. A medical provider can request reanalysis of the variants, and this is recommended on an annual basis. Data from this next-generation sequencing analysis can be reassessed for the presence of any new variants that may be newly linked to established genes or to newly characterized genes and/or disorders identified since the data used in this report was generated. A charge may be applied for reanalysis. Please contact support@meenta.io for more information at the time reanalysis is requested.

 

Cheek swab in viral transport media shipped at room temperature

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