Lynch Syndrome Sequencing

Purpose: Detect risk of Lynch Syndrome

Benefits:

• Analyzes 5 genes involved in detecting Lynch Syndrome
• Helps inform helpful healthcare and lifestyle changes
• Reveals genetic risk in yourself and close relatives
• Comprehensive genetic test
• Outlines hereditary mutations that can reveal increased risk to future generations

Sample type: Cheek swab

Technology: Next Generation Sequencing

Turnaround time: 3-4 weeks from receipt in lab

Lynch syndrome, also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC), is a hereditary defect in one of five genes that can lead to various cancers, especialy colorectal and endometrial.  In the past, most people do not know they have this syndrome until a cancer develops.  However, the risk of Lynch Syndrome increases if there is a family history of cancer,  especially if there are three or more family members with cancer,  This risk increases even more if one is a first-degree relative and the other two have HNPCC-related cancer  and if it is successive affected generations. Once identified, it depends on which of the five genes is affected as to what symptoms or cancer the person gets so it is important to identify any gene mutation to determine the type of cancer which may become problematic.  

This test includes: EPCAM,  MLH1, MSH2, MSH6, PMS2

How do I interpret the results?

Genetic counseling is generally recommended for any individual taking this test and their family. A medical provider can request reanalysis of the variants, and this is recommended on an annual basis. Data from this next-generation sequencing analysis can be reassessed for the presence of any new variants that may be newly linked to established genes or to newly characterized genes and/or disorders identified since the data used in this report was generated. A charge may be applied for reanalysis. Please contact support@meenta.io for more information at the time reanalysis is requested.

Cheek swab in viral transport media shipped at room temperature