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Precision Genetic Testing for Mental Health + ADHD Markers (Providers Only)

Precision Genetics
SKU: PGMH02

$498.75 per test

Customize your patient’s mental health medication plan using their own genetic data. Just order a collection kit, collect and mail your patient’s buccal swab sample to the lab, and within two weeks you’ll have the data you need to recommend an evidence-based treatment plan. This test also includes ADHD-related genetic information.

Customize your patient’s mental health medication plan using their own genetic data. Just order a collection kit, collect and mail your patient’s buccal swab sample to the lab, and within two weeks you’ll have the data you need to recommend an evidence-based treatment plan. This test also includes ADHD-related genetic information.

The Fine Print

Neuropharmagen: revolutionary genetic test panel for managing medicine 

Did you know that:

  • 82% of Americans take at least one medication.
  • The FDA says that 50% of medications taken by patients are ineffective.
  • Adverse Drug Reactions (ADR) are the 4th leading cause of death in the United States.
  • 20-30% of health care benefit costs are prescriptions.
  • Prescription costs increase 3-9% every year.

Personalized genetic testing for mental health can help make it easier for you to take action on your health program. This service provides genetic testing for mental health that helps identify the safest and most appropriate medication for mental health patients based on their DNA. Whether for individual patients or an organization, this test can improve clinical outcomes in children and adults taking mental health-related medication. Reduce the trial and error in your medication management to see improvement in mental health. It takes into account the patient’s full drug regimen, drug interactions, genetics, lifestyle, ethnicity, and age all prior to delivery of the care management results report to the practitioner

  • Summary table showing all the drugs classified according to the therapeutic family they belong to. Each drug is associated with a green, yellow red color box that summarized the results (response likely, dose adjustment or monitoring, increased risk).
  • The detailed results per drug also include an interpretation of the findings.
  • The additional genetic information of the biological role of the genes for which a specific patient carries relevant variants.

*Main benefits reported from doctors already using this genetic testing for mental health:

A 12-week, double-blind, parallel, multi-center randomized controlled trial in 316 adult patients with major depressive disorder was conducted to evaluate the effectiveness of testing for drug therapy guidance.

  • 42% reported patients’ stabilization
  • 28% reported reduction in adverse drug effects
  • 25% reported increased treatment adherence
  • 7.5% reported crisis reduction

 Genetic Insights for Informed Decision Making 

  • evidence-based
  • clinically proven
  • single, non-invasive buccal swab
  • pain-free
  • advanced genetic guidance for the life of the patient
  • easily accessible by computer, tablet or phone
  • cloud-based physician decision support tool
  • most comprehensive list of mental health medications on the market
  • ADHD report available 

Clinical Studies 

A specialized mental health genetic test with level 1 and level 2 evidence in multicenter study both for improvement of efficacy and tolerability, performed in naturalistic population: 

 

If you’re interested in more general panels for pharmacogenetics, check out this one here.

Cheek Swab Sample Collection

The office will have a supply of collection kits in storage. Take one sample collection packet per patient. Follow the sample collection instructions within the packet. The collection packet contains specimen labels where you can hand write the patient’s name and DOB; however, if the office has a printer, you can print a bar code label as well.

Shipping

It is recommended that the specimen ship the same day, if possible.    If the specimen is collected late in afternoon, it can be sent out the next morning.  Samples can be shipped using any carrier available to your office as long as the package can be tracked. Sample be dropped off at a shipping location or picked up at your office.

Results

Turnaround time is about 5-14 days.

Potential Reasons People Take This Test

  • Polypharmacy-related: Patients on 5 or more medications (the technical definition of polypharmacy as per [1]) and where you believe polypharmacy-related drug-drug interactions may be creating health issues (e.g. falls, delirium, side effects, depression etc.).
  • Treatment-resistant depression-related: Genetic information would likely be most beneficial for individuals who have experienced an inadequate response or adverse reaction to a previous antidepressant or antipsychotic trial. Based on [2] and [3].
  • High Trial-and-error failure rates: A patient’s frustration can lead to them giving up on taking any medications due to not only the failure of therapeutic effects but significant side effects they feel.
  • High-risk CYP450 medications: Patients taking medication from below and 2 other medications. As per protocol from [4].

Generic (CYP450): Amitriptyline (CYP2D6, CYP2C19),   Aripiprazole (CYP2D6),   Atomoxetine (CYP2D6),   Carvedilol (CYP2D6),   Celecoxib (CYP2C9),   Citalopram (CYP2C19),   Clobazam (CYP2C19),   Clomipramine (CYP2D6),   Clopidogrel (CYP2C19),   Clozapine (CYP2D6),   Codeine (CYP2D6),   Desipramine (CYP2D6),   Dextromethorphan (CYP2D6),   Diazepam (CYP2C19),   Doxepin (CYP2D6, CYP2C19),   Escitalopram (CYP2C19),   Esomeprazole (CYP2C19),   Fesoterodine (CYP2D6),   Flecainide (CYP2D6),   Acetaminophen/oxycodone (CYP2D6),   acetaminophen/hydrocodone (CYP2D6), Fluoxetine (CYP2D6, CYP2C19),   Flurbiprofen (CYP2C9),   Fluvoxamine (CYP2D6),   Haloperidol (CYP2D6),   Hydrocodone (CYP2D6),   Ibuprofen (CYP2C9),   Iloperidone (CYP2D6),   Imipramine (CYP2D6, CYP2C19), Indomethacin (CYP2C9),   Meloxicam (CYP2C9),   Metoprolol (CYP2D6),   Mexiletine (CYP2D6),   Nortriptyline (CYP2D6),   Omeprazole (CYP2C19),   Oxycodone (CYP2D6),   Paroxetine (CYP2D6),   Perphenazine (CYP2D6),   Phenobarbital (CYP2C9, CYP2C19), Phenytoin (CYP2C9, CYP2C19), Acetaminophen/tramadol (CYP2D6), Dextromethorphan/guaifenesin (CYP2D6 Pimozide (CYP2D6),   Piroxicam (CYP2C9),   Proguanil (CYP2C19),   Propafenone (CYP2D6),   Propranolol (CYP2D6),   Risperidone (CYP2D6),   Sertraline (CYP2C19),   Tetrabenazine (CYP2D6),   Thioridazine (CYP2D6),   Timolol (CYP2D6),   Tolterodine (CYP2D6),   Torsemide (CYP2C9),   Tramadol (CYP2D6),   Trimipramine (CYP2D6),   Venlafaxine (CYP2D6),   Voriconazole (CYP2C19),   Vortioxetine (CYP2D6), Chlorpheniramine/hydrocodone (CYP2D6),   Acetaminophen/codeine (CYP2D6).

References

  1. Masnoon, N., et al., What is polypharmacy? A systematic review of definitions. BMC Geriatr, 2017. 17(1): p. 230.
  2. ISPG. Genetic Testing Statement: Genetic Testing and Psychiatric Disorders: A Statement from the International Society of Psychiatric Genetics. 2019  17/05/19]; Available from: https://ispg.net/genetic-testing-statement/.
  3. Polasek, T., K. Mina, and G. Suthers, Pharmacogenomics in general practice: The time has come. Australian Journal of General Practice, 2019. 48(3).
  4. Brixner, D., et al., The effect of pharmacogenetic profiling with a clinical decision support tool on healthcare resource utilization and estimated costs in the elderly exposed to polypharmacy. J Med Econ, 2016. 19(3): p. 213‐28.

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