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Precision Genetics

Precision Genetics Neuropharmagen Testing for Mental Health + ADHD Markers

$399.00 per test

  • Purpose: This is a genetic test to help identify the safest and most appropriate psychotropic medication for mental health patients
  • Benefits: Choose the correct medications faster, reducing wasted time and expenses on drugs that won’t work
  • Technology: RT-PCR-based genetic test on cheek swab samples resulting in a PDF report of specific medication recommendations (1-2 week turnaround time)

Check out this video to learn more!

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Description

Key Features

  • Improve mental health-related medication plans: This product tests for a panel of genetic variants for drug-metabolizing enzyme (DME) genes and genes associated with mental health medications.
  • Useful for and mental health medication plan: This product is recommended for patients taking commonly known medications.
  • Specimen Type: Buccal Swab (inner cheek swab).
  • Report included: Report (pdf) of genetic results and recommendations regarding medications, dosing, and alternatives.
  • Turnaround Time: 1-2 weeks after the lab receives samples
Product Details

Neuropharmagen: revolutionary genetic test panel for managing medicine 

Did you know that:

  • 82% of Americans take at least one medication.
  • The FDA says that 50% of medications taken by patients are ineffective.
  • Adverse Drug Reactions (ADR) are the 4th leading cause of death in the United States.
  • 20-30% of health care benefit costs are prescriptions.
  • Prescription costs increase 3-9% every year.

Personalized genetic testing for mental health can help make it easier for you to take action on your health program. This service provides genetic testing for mental health that helps identify the safest and most appropriate medication for mental health patients based on their DNA. Whether for individual patients or an organization, this test can improve clinical outcomes in children and adults taking mental health-related medication. Reduce the trial and error in your medication management to see improvement in mental health. It takes into account the patient’s full drug regimen, drug interactions, genetics, lifestyle, ethnicity, and age all prior to delivery of the care management results report to the practitioner

  • Summary table showing all the drugs classified according to the therapeutic family they belong to. Each drug is associated with a green, yellow red color box that summarized the results (response likely, dose adjustment or monitoring, increased risk).
  • The detailed results per drug also include an interpretation of the findings.
  • The additional genetic information of the biological role of the genes for which a specific patient carries relevant variants.

*Main benefits reported from doctors already using this genetic testing for mental health:

A 12-week, double-blind, parallel, multi-center randomized controlled trial in 316 adult patients with major depressive disorder was conducted to evaluate the effectiveness of testing for drug therapy guidance.

  • 42% reported patients’ stabilization
  • 28% reported reduction in adverse drug effects
  • 25% reported increased treatment adherence
  • 7.5% reported crisis reduction

Genetic Insights for Informed Decision Making 

  • evidence-based
  • clinically proven
  • single, non-invasive buccal swab
  • pain-free
  • advanced genetic guidance for the life of the patient
  • easily accessible by computer, tablet or phone
  • cloud-based physician decision support tool
  • most comprehensive list of mental health medications on the market
  • ADHD report available 

Clinical Studies 

A specialized mental health genetic test with level 1 and level 2 evidence in multicenter study both for improvement of efficacy and tolerability, performed in naturalistic population: 

Can I see an example report?

Yes, an example report can be found here.

Potential Reasons People Take This Test

  • Polypharmacy-related: Patients on 5 or more medications (the technical definition of polypharmacy as per [1]) and where you believe polypharmacy-related drug-drug interactions may be creating health issues (e.g. falls, delirium, side effects, depression etc.).
  • Treatment-resistant depression-related: Genetic information would likely be most beneficial for individuals who have experienced an inadequate response or adverse reaction to a previous antidepressant or antipsychotic trial. Based on [2] and [3].
  • High Trial-and-error failure rates: A patient’s frustration can lead to them giving up on taking any medications due to not only the failure of therapeutic effects but significant side effects they feel.
  • High-risk CYP450 medications: Patients taking medication from below and 2 other medications. As per protocol from [4].

What does this test measure?

This test provides coverage of 34 genes covering 59 psychoactive drugs and other important genetic markers. You can find a comprehensive description of the test here.

References

  1. Masnoon, N., et al., What is polypharmacy? A systematic review of definitions. BMC Geriatr, 2017. 17(1): p. 230.
  2. ISPG. Genetic Testing Statement: Genetic Testing and Psychiatric Disorders: A Statement from the International Society of Psychiatric Genetics. 2019  17/05/19]; Available from: https://ispg.net/genetic-testing-statement/.
  3. Polasek, T., K. Mina, and G. Suthers, Pharmacogenomics in general practice: The time has come. Australian Journal of General Practice, 2019. 48(3).
  4. Brixner, D., et al., The effect of pharmacogenetic profiling with a clinical decision support tool on healthcare resource utilization and estimated costs in the elderly exposed to polypharmacy. J Med Econ, 2016. 19(3): p. 213‐28.

If you’re interested in more general panels for pharmacogenetics, check out this one here.

Sample Details

Cheek Swab Sample Collection

The office will have a supply of collection kits in storage. Take one sample collection packet per patient. Follow the sample collection instructions within the packet. The collection packet contains specimen labels where you can hand write the patient’s name and DOB; however, if the office has a printer, you can print a bar code label as well.

Collection Kit Includes:

  • One Cotton Swab (inside of plastic tubes)
  • One Plastic Collection Tubes
  • Test Requisition Form
  • Medication/Supplements & Lifestyle Factor Form
  • One Sealable Bio Bag

Sample Collection Instructions:

  1. Please have patient refrain from smoking, chewing tobacco, eating, or drinking at least 60 minutes prior to collecting samples.
  2. Briefly rinse the patient’s mouth twice with water and have them spit it out each time. Do not swallow.
  3. Fill out all required information on the Precision Genetics Test Requisition Form.
  4. Open the tube and remove the swab being careful not to handle the flocked end.
  5. Insert the flocked end into the patient’s mouth and rub firmly against the inside of the cheek and underneath lower or upper lip. Rub for 30 seconds to 1 minute.
  6. Place swab back into provided plastic tube and close the tube securely. Do not touch the flocked end with your fingers.
  7. Insert completed Genetic Test Requisition Form, medication/supplements & lifestyle factor form, and provided plastic collection tubes and swabs samples into the sealable bio bags followed by the provided pre paid mailing envelope(s).
  8. Drop off in a timely manner as directed.
Payment Methods
  • Credit Card
  • HSA Card
  • ACH
  • PayPal
  • PO Number

Note: These products and services are not returnable. Check your kit expiration date upon receipt. Using expired test kits is not recommended because they may provide inaccurate results.

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Questions?

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