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Strand Analytics Clinical Exome (All Pathogenic/ Likely pathogenic variants)

$120.00 per sample

Variations are identified using Strand’s integrated proprietary software STRAND®NGS – which provides analysis, management and visualization tools for next-generation sequencing data, and interpreted using Strand’s proprietary interpretation and reporting platform StrandOmics™ –   which combines bioinformatics algorithms, public data from external sources/knowledge databases, visualization interfaces and reporting capabilities.


Strand clinical interpretation service is driven by an expert and clinically trained team of variant scientists and medical geneticists, who aid in the professional review and sign-out of clinical NGS reports. The variant interpretation and reporting will be supported by Strand’s secondary/tertiary analysis tools STRAND®NGS and StrandOmics™. STRAND®NGS enables the secondary analysis of (FASTQ) data generated from next-generation sequencing (NGS) experiments, and supports extensive workflows for the analysis and visualization of a range of NGS data including DNA-Seq data from whole genome, whole exome or targeted resequencing experiments. StrandOmics™, a proprietary and robust platform for tertiary analysis and report generation, is a semi-automated pipeline that starts with VCF files, allows easy and secure data upload through the web interface, and also has a curation on the fly portal, which enables rapid curation on new variants. It is comprehensive and accepts all variant types, including reporting on variants in pseudogenes.

Product Details
The STRAND®NGS automated pipeline comprises of (a) read alignment to reference genome, (b) read quality assessment, (c) stringent filtering to eliminate false positive and low quality reads, and (d) variant calling with an ability to detect SNPs, MNPs, and sort InDels, as well as large structural variations, including large insertions, deletions, inversions, and translocations.
The overall pipeline supported by the StrandOmics™ platform starts with the VCF file, which along with coverage gets uploaded in the tool, and calls out the low coverage region (<20 reads). The ‘interpretation interface’ then  allows quick filtering and evaluation of variants identified in a sample via (a) algorithms that assist in identifying variant impact from both public content (public data sources) and proprietary content (~40 000 extra curated variant records) on genes, phenotypes and diseases, (b) integrated in silico prediction tools, (c) integrated data sources that evaluate sequences conservation, and (d) integrated knowledge used to automatically prioritize and pre-classify the filtered list of variants, based on American College of Medical Genetics and Genomics (ACMG) guidelines, the inheritance model, disease phenotype, as well as the integrated tools and data. Template-driven reports and exclusive 3-layer review by Strand’s experienced team of scientists ensures to avoid any error. The reporting format is fully customizable according to the preferred unique branding policy.
Sample Details

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Note: These products and services are not returnable. Check your kit expiration date upon receipt. Using expired test kits is not recommended because they may provide inaccurate results.


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